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  • Title: Urinary 3-methylhistidine derivative as indicator of nutrients intake in low-birth-weight infants.
    Author: Gil A, Faus MJ, Robles R, Pita ML, Sánchez-Pozo A, Linares MD, Sánchez-Medina F.
    Journal: Horm Metab Res; 1984 Dec; 16(12):667-70. PubMed ID: 6526369.
    Abstract:
    Urinary excretion levels of N-methylhistidine derivatives and N-methylhistidine/creatinine ratios were studied in a group of 20 small for date newborns, 10 premature infants and 8 normal infants, at birth and at one week of life. All infants were fed with an adapted milk formula supplying 2.8 g protein/kg body weight. 1-methyl and 3-methylhistidine urinary excretion were increased in all groups of infants from birth to the 7th day of life. Creatinine and N-methyl derivatives/creatinine ratios were also significantly increased at one week of life. The two ratios showed a higher level in small for date and premature infants than in normal infants at birth which continued relatively increased at one week of life. 3-methyl-histidine/creatinine ratio appears as a useful indicator of the turnover rate of muscular proteins in low-birth-weight infants.
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