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  • Title: Nifedipine in scleroderma ulcerations.
    Author: Woo TY, Wong RC, Campbell JP, Goldfarb MT, Voorhees JJ, Callen JP.
    Journal: Int J Dermatol; 1984 Dec; 23(10):678-80. PubMed ID: 6526563.
    Abstract:
    Cutaneous ulcerations may be due to a variety of causes, including vasculitis, infections, arterial insufficiency, and microvascular damage. The net effect is diminished blood flow to the skin. Nifedipine, a calcium antagonist, has been shown to improve cutaneous blood flow and to alleviate reactive vasospastic ischemia (Raynaud's phenomenon). The authors report an ischemic ulcer of scleroderma showing visible improvement with nifedipine therapy.
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