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  • Title: [Abnormalities in the erythrocyte membrane transport of oxalate in calcium oxalate lithogenesis].
    Author: Baggio B, Gambaro G, Marchini F, Cicerello E, Borsatti A.
    Journal: Nephrologie; 1984; 5(4):173-4. PubMed ID: 6527719.
    Abstract:
    The high incidence of a family history and the observation of abnormally high intestinal absorption and urinary excretion of oxalate suggest to consider idiopathic calcium oxalate nephrolithiasis as a metabolic disease characterized by a disorder in oxalate transport. To test this hypothesis, the flux of 14C Oxalate through the membrane of red blood cells was investigated in 24 calcium oxalate stone formers; 18 of the 24 "idiopathic" calcium oxalate stone formers showed an increased oxalate self exchange (75%). Our data seem to support the possibility that "idiopathic" calcium oxalate nephrolithiasis may be considered as a metabolic disease marked by a defect in transmembrane transport of oxalate.
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