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  • Title: [Effect of isatin and its derivatives on some indicators of carbohydrate metabolism].
    Author: Garalene VN, Mazhilis LI.
    Journal: Vopr Med Khim; 1984; 30(5):56-9. PubMed ID: 6528521.
    Abstract:
    Effect of isatin and of three its derivatives on content of lactate, pyruvate and glycogen was studied in rat tissues. The substances studied, except of 5-butylisatin, decreased the content of lactic acid with simultaneous increase of glycogen content in liver tissue under normal conditions. The pyruvate content was most markedly altered in presence of 5-bromoisatin and 5-butylisatin. In deficiency of oxygen a distinct increase in content of lactate and pyruvate was noted in animal tissues after the 5-bromoisatin preadministration. Under conditions of oxygen deficiency the substances studied were of distinct significance for more economical utilization of glycogen in liver tissue and skeletal muscles.
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