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  • Title: Buspirone increases locus coeruleus noradrenergic neuronal activity in vitro.
    Author: Trulson ME, Henderson LJ.
    Journal: Eur J Pharmacol; 1984 Oct 30; 106(1):195-7. PubMed ID: 6529967.
    Abstract:
    Buspirone, a non-benzodiazepine anxiolytic agent, produced dose-dependent increases in the activity of norepinephrine-containing locus coeruleus neurons recorded from mouse brain slices in vitro. The response was not changed in a low calcium/high magnesium incubation medium, indicating that the observed effects were the result of a direct action of buspirone on locus coeruleus neurons. These data suggest that noradrenergic neurons may not be as important in mediating anxiety states as previously suggested.
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