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  • Title: Gastrointestinal cytoprotection by indomethacin + sodium salicylate combination in rat.
    Author: Ezer E, Matuz J, Pallagi K, Szporny L.
    Journal: Acta Physiol Hung; 1984; 64(3-4):355-9. PubMed ID: 6532123.
    Abstract:
    Non-steroidal antiinflammatory agents are well known to cause gastrointestinal damage in many species including the rat and human. Pelsonin a combination of indomethacin and sodium salicylate (1:10 ratio) has a cytoprotective effect against acidic-alcohol induced gastric necrosis, and it does not induce intestinal ulceration. Pelsonin is capable of blocking the formation of intestinal ulcers induced by oral indomethacin 10 mg/kg (curative cytoprotection). The cytoprotective potency of Pelsonin is due to sodium salicylate.
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