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  • Title: Nonvolatile N-nitrosamine investigations: methods for the determination of N-nitrosoamino acids and preliminary results of the development of a method for the determination of N-nitrosodipeptides N-terminal in proline.
    Author: Kubacki SJ, Havery DC, Fazio T.
    Journal: IARC Sci Publ; 1984; (57):145-58. PubMed ID: 6533002.
    Abstract:
    The development of a rapid method for the determination of N-nitrosoamino acids is reported. Preliminary recoveries of N-nitrosoamino acids in ham fortified with 20 micrograms/kg generally ranged from 70 to 100%. The synthesis and instrumental characterization of four N-nitrosodipeptides N-terminal in proline from nitrite in aqueous acid solution are reported. Electron ionization-mass spectroscopy and infra-red spectroscopy strongly support the conclusion that only the amine nitrogen, and not the amide nitrogen at the peptide bond, is nitrosated. High-performance liquid chromatographic conditions are described for the separation of the synthesized N-nitrosodipeptides.
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