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  • Title: Metabolism of nitrosamines by cytochrome P-450 isozymes.
    Author: Yang CS, Tu YY, Hong J, Patten C.
    Journal: IARC Sci Publ; 1984; (57):423-8. PubMed ID: 6533032.
    Abstract:
    Results are presented to show that N-nitrosodimethylamine demethylase is P-450 mediated and N-nitrosodimethylamine is efficiently metabolized by specific P-450 isozymes inducible by a group of new inducers. The P-450-mediated N-nitrosodimethylamine demethylase also responds differently to inhibitors when activities are compared with those of classical monooxygenase systems.
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