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  • Title: 15-Deacetylsergeolide, a potent antileukemic quassinoid from Picrolemma pseudocoffea.
    Author: Polonsky J, Bhatnagar S, Moretti C.
    Journal: J Nat Prod; 1984; 47(6):994-6. PubMed ID: 6533270.
    Abstract:
    Investigation of the leaf extract of Picrolemma pseudocoffea afforded a new antineoplastic quassinoid, 15-deacetylsergeolide (3), and two known quassinoids, isobruceine B (1) and sergeolide (2). The structure of 3, which displayed strong antileukemic activity in the P-388 test system, was established through the interpretation of spectral data and chemical correlation to 2.
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