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  • Title: IgG, IgA, IgM and IgE serum levels in asthmatic patients sensitive to house dust and mite allergens after two-year specific immunotherapy.
    Author: Szymański W, Chyrek-Borowska S, Obrzut D.
    Journal: Arch Immunol Ther Exp (Warsz); 1984; 32(4):381-7. PubMed ID: 6534314.
    Abstract:
    The investigations were carried out on 36 atopic asthma patients treated with a specific allergen vaccine--Allpyral. The serum immunoglobulin levels, specific IgE blocking antibodies were determined by various immunological methods. It was shown that a marked rise in the IgG level appeared after 6 months of therapy and maintained during the whole period of observation. This higher IgG level was often correlated with an increase in blocking antibody titer. IgE serum revealed a higher value after 6 months, but on prolongation of the immunotherapy the total IgE level decreased not statistically significantly. The specific IgE antibody showed a tendency to fall after 2-year hyposensitization. The most marked changes in the behaviour of specific IgE and blocking antibodies were observed in the patients with clinical improvement.
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