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  • Title: Suppression of xenogeneic local graft versus host reaction by rat fetal spleen cells.
    Author: Skowron-Cendrzak A, Rybczyńska Z, Sajak A, Dobrowolski Z.
    Journal: Arch Immunol Ther Exp (Warsz); 1984; 32(4):443-6. PubMed ID: 6534317.
    Abstract:
    Xenogeneic local graft versus host reaction was induced by the injection of 5 X 10(7) adult rat spleen cells under the capsule of cyclophosphamide-treated adult mice. A significant decrease in the reaction, measured by the kidney enlargement index, was obtained by adding to the reacting cells 5-20% of fetal rat spleen cells. Fetal rat thymocytes of fetal mouse splenocytes were not found to be inhibitory. The suppressive activity of rat spleen cells waned completely on day 3 of the postnatal life.
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