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  • Title: Synthesis and pharmacological properties of the products of condensation of tryptamine derivatives with pyridoxal.
    Author: Misztal S, Boksa J, Grabowska M, Chojnacka-Wójcik E, Tatarczyńska E.
    Journal: Pol J Pharmacol Pharm; 1984; 36(6):689-96. PubMed ID: 6535159.
    Abstract:
    Four new derivatives of 1,2,3,4-tetrahydro-beta-carboline 2a--d were synthetized with the pyridoxal moiety in position 1; there were also obtained four Schiff bases 1a--d which are intermediate products in this synthesis. Schiff bases 1a--d revealed a sedative and analgesic action, and compound 1b also had potential antidepressive properties. The derivatives of tetrahydro-beta-carboline 2a--d were inactive in the carried out tests.
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