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  • Title: The effect of prosthetic gallstones on total bile acid pool size in dogs.
    Author: Thurston OG, McDougall RM, Walker K.
    Journal: Surg Gynecol Obstet; 1978 Jun; 146(6):911-3. PubMed ID: 653567.
    Abstract:
    A reduction in total bile acid pool size was noted in nine of ten dogs after the implantation of inert prosthetic gallstones. Sham cholecystotomy without implantation of a prosthesis also produced a small decrease in bile acid pool size but was significantly less than the decrease noted with prosthetic stones. Bile acid ratios--cholic acid, chenodeoxycholic acid and deoxycholic acid--did not change after implantation of prosthetic stones. These findings raise the possibility that the small total bile acid pool size noted in patients with cholesterol gallstones is a phenomenon secondary to the pathologic state of the gallbladder.
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