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  • Title: Delta-aminolaevulinic acid metabolism in normal and lead-exposed humans.
    Author: Meredith PA, Moore MR, Campbell BC, Thompson GG, Goldberg A.
    Journal: Toxicology; 1978 Feb; 9(1-2):1-9. PubMed ID: 653730.
    Abstract:
    The activity of the haem biosynthetic enzymes delta-aminolaevulinic acid synthetase (ALA.S) and delta-aminolaevulinic acid dehydratase (ALA.D) were measured in the peripheral blood of a group of lead workers and control subjects. The haem precursor delta-aminolaevulinic acid (ALA) was measured in blood and urine, whilst lead levels were measured in whole blood. The inter-relationships between all these parameters were examined and quantified. The results demonstrate that above a blood lead concentration of 2 mumole/l and below an erythrocyte ALA.D activity of 18 nmole ALA utlized/min/ml red blood cells (R.B.C.), Haem synthesis is depressed to such an extent that the activity of leucocyte ALA.S, the rate-limiting enzyme of haem biosynthesis, is increased by negative feedback.
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