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  • Title: Crosslinking of tropomyosin to myosin subfragment-1 in reconstituted rabbit skeletal thin filaments.
    Author: Tao T, Lamkin M.
    Journal: FEBS Lett; 1984 Mar 12; 168(1):169-73. PubMed ID: 6538513.
    Abstract:
    Rabbit skeletal tropomyosin was labeled with the bifunctional photoactivatable crosslinker N-succinimidyl-6- (4'-azido-2'-nitrophenylamino)hexanoate. After irradiating the rigor complex composed of myosin subfragment-1, crosslinker-labeled tropomyosin, and F-actin, a crosslinked product was formed. This product was identified as a 1:1 adduct of tropomyosin and subfragment-1. This finding is in support of recent structural studies which suggest that tropomyosin and subfragment-1 are in close proximity to each other, and may be relevant to the mechanism of thin filament regulation.
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