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  • Title: An unusual case of generalized ceroid-lipofuscinosis in a cynomolgus monkey.
    Author: Jasty V, Kowalski RL, Fonseca EH, Porter MC, Clemens GR, Bare JJ, Hartnagel RE.
    Journal: Vet Pathol; 1984 Jan; 21(1):46-50. PubMed ID: 6538717.
    Abstract:
    Histologic, histochemical, and electron microscopic studies of generalized ceroid-lipofuscinosis in a cynomolgus monkey are presented. Histologically, a wide variety of tissue cells contained numerous bright eosinophilic intracytoplasmic granules that varied in size from 0.5 micron to 4.0 microns in diameter. Histochemically, the granules gave a weakly positive reaction with periodic acid-Schiff and for lipids. They were weakly acid fast and capable of emitting autofluorescence. Ultrastructurally, the granules were single unit membrane-bound, and contained dense osmiophilic material with frequent concentric or fingerprint-type lamellar formation. The granules were different than hemofuscin, iron, and bilirubin. Tinctorially the granules were unique--they were bright red with hematoxylin and eosin and, thus, differed from typical age-related lipofuscin pigment.
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