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  • Title: Dysfibrinogenemia (fibrinogen Dusard) associated with impaired fibrin-enhanced plasminogen activation.
    Author: Lijnen HR, Soria J, Soria C, Collen D, Caen JP.
    Journal: Thromb Haemost; 1984 Feb 28; 51(1):108-9. PubMed ID: 6539000.
    Abstract:
    The fibrin-mediated enhancement of the activation of plasminogen by tissue-type plasminogen activator observed with normal fibrin, is strongly decreased with fibrin Dusard, although the binding of tissue-type plasminogen activator to this fibrin is normal. This impaired fibrin-mediated plasminogen activation is most likely related to the history of recurrent thrombosis and pulmonary embolism observed in this family.
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