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  • Title: Carcinogenicity in mice of mutagenic compounds from glutamic acid and soybean globulin pyrolysates.
    Author: Ohgaki H, Matsukura N, Morino K, Kawachi T, Sugimura T, Takayama S.
    Journal: Carcinogenesis; 1984 Jun; 5(6):815-9. PubMed ID: 6539177.
    Abstract:
    2-Amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole and 2- aminodipyrido [1,2-a:3',2'-d]imidazole, potent mutagens from glutamic acid pyrolysate, were given orally to CDF1 mice of both sexes at concentrations of 0.05% in pellet diet. 2-Amino-3-methyl-9H-pyrido[2,3-b]indole and 2-amino-9H-pyrido[2,3-b]indole, potent mutagens from soybean globulin pyrolysate, were given to CDF1 mice of both sexes at concentrations of 0.08%. Hepatocellular carcinomas and hemangioendothelial sarcomas in the brown adipose tissue were induced in high incidence by all these compounds.
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