These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Ethanol and pentobarbital have different behavioral effects in the rat.
    Author: Schechter MD.
    Journal: Prog Neuropsychopharmacol Biol Psychiatry; 1984; 8(2):271-6. PubMed ID: 6539934.
    Abstract:
    Stimulus control was established in rats with 600 mg/kg ethanol and saline by employing a two-lever response choice task and an FR10 schedule of food reinforcement. Once trained, rats were tested with lower doses of ethanol (300 and 450 mg/kg) and with pentobarbital (0.75 - 4.0 mg/kg). The 3.0 and 4.0 mg/kg doses of pentobarbital were observed to produce ethanol-like responding and decreasing doses of both ethanol and pentobarbital produced dose-related effects upon discriminative performance. The ED50 for ethanol was 372 mg/kg and for pentobarbital was 1.09 mg/kg. Graphic representation of the dose-response relationships suggested that these drugs possess different sites and/or mechanisms of action.
    [Abstract] [Full Text] [Related] [New Search]