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  • Title: High-dose intravenous IgG for chronic idiopathic thrombocytopenic purpura in adults.
    Author: Lang JM, Faradji A, Giron C, Bergerat JP, Oberling F.
    Journal: Blut; 1984 Aug; 49(2):95-9. PubMed ID: 6540611.
    Abstract:
    Sixteen adult patients of mean age 48 years with chronic ITP were studied for platelet response to high-dose (0.4 g/kg body weight per day for five consecutive days) intravenous polyvalent intact IgG in the absence of any concurrent treatment. The platelet count returned to normal values in nine patients, a partial response (rise in the platelet count between 50 and 150 X 10(9)/1) was observed in three cases. One patient refractory to any other treatment went into a sustained remission. In the other responsive patients the response was only transient. Among seven splenectomised patients only three responded to IgG infusions versus nine in the non-splenectomised group. The length of ITP history appeared as a more critical factor for the response to IgG than previous splenectomy.
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