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  • Title: Effect of some selected anti-inflammatory steroids on elastin content in liver of rats treated with carbon tetrachloride.
    Author: Olczyk K, Drózdz M, Piwowarczyk B, Kucharz E.
    Journal: Exp Clin Endocrinol; 1984 May; 83(3):353-7. PubMed ID: 6540703.
    Abstract:
    Hepatic fibrosis was induced in rats by poisoning them with carbon tetrachloride. The influence of anti-inflammatory steroids (hydrocortisone, prednisone, dexamathasone) upon elastin content in liver was investigated in healthy and CCl4 intoxicated rats. An increase of liver elastin content was observed in animals with CCl4-induced hepatic fibrosis Opposite results were obtained in normal rats after treating them with glucocorticosteroids. A decrease of elastin content after steroid treatment was also found in rats with injured liver, as compared to animals receiving CCl4 only. Presumable mechanisms of the results are discussed.
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