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  • Title: Choroidal microvascular repair after argon laser photocoagulation. Ultrastructural observations.
    Author: Perry DD, Reddick RL, Risco JM.
    Journal: Invest Ophthalmol Vis Sci; 1984 Sep; 25(9):1019-26. PubMed ID: 6540760.
    Abstract:
    Acute laser injury to the tapetum of the feline retina produces thrombosis of the choriocapillaris. Early changes are characterized by the appearance of platelet-fibrin thrombi within capillary loops and disruption of endothelial integrity. By 4 days, thrombi have disappeared, and the endothelium shows regenerative changes. No endothelial cell mitotic activity is seen. The endothelial cytoplasm becomes plump, and there is a loss of the fenestrations adjacent to Bruch's membrane. By 10-20 days, the capillary structure shows gradual restoration. At 30 days, endothelial cell fenestrae are clearly evident adjacent to Bruch's membrane. The reparative process in this model appears to evolve as a result of thrombolysis and endothelial cell activation.
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