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  • Title: Effect of topically applied forskolin on aqueous humor dynamics in cynomolgus monkey.
    Author: Lee PY, Podos SM, Mittag T, Severin C.
    Journal: Invest Ophthalmol Vis Sci; 1984 Oct; 25(10):1206-9. PubMed ID: 6541215.
    Abstract:
    Topical administration of a 1% forskolin suspension significantly reduced intraocular pressure in cynomolgus monkey eyes. The fall in intraocular pressure was associated with a significant (P less than 0.01) decrease in aqueous humor flow measured by a fluorophotometric technique. No significant change was found in tonographic outflow facility or pupillary diameter. A loss of effect on intraocular pressure to subsequent doses of 1% forskolin suspension occurred in cynomolgus monkeys by the third day of twice-a-day treatment.
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