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Title: Treatment of Lambert-Eaton syndrome: 3,4-diaminopyridine and pyridostigmine. Author: Lundh H, Nilsson O, Rosén I. Journal: Neurology; 1984 Oct; 34(10):1324-30. PubMed ID: 6541305. Abstract: We used a new drug, 3,4-diaminopyridine, to treat five patients with the Lambert-Eaton syndrome, one with a carcinoma and four cryptogenic. The effects of intravenous, oral, and rectal administration were evaluated clinically and electrophysiologically after single doses and during continuous treatment for up to 21 months. 3,4-Diaminopyridine effectively ameliorated the neuromuscular and autonomic nervous system disorders without severe side effects. Anticholinesterase drugs strongly potentiated the benefit of 3,4-diaminopyridine.[Abstract] [Full Text] [Related] [New Search]