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  • Title: Influence of strain and age on the induction of mammary tumours by diethylstilboestrol in C3H mice.
    Author: Greenman DL, Kodell RL, Highman B, Schieferstein GJ, Norvell M.
    Journal: Food Chem Toxicol; 1984 Nov; 22(11):871-4. PubMed ID: 6542052.
    Abstract:
    C3H/HeJ and C3H/HeN female mice were fed diets containing targeted concentrations of 320 or 640 ppb diethylstilboestrol (DES) starting at 7 or 11 wk of age and continuing throughout their remaining lifespan. Regardless of the DES concentration there was a faster rate of development and higher final incidence of mammary adenocarcinomas among the C3H/HeN mice than among the C3H/HeJ mice. In C3H/HeN mice started on DES when 11 wk old, mammary tumours developed more rapidly than when treatment was started at 7 wk of age. This was also true for C3H/HeJ mice given 320 ppb DES but not for those treated with 640 ppb DES. Both age at the start of treatment and strain of C3H mice are important factors to be considered in designing experiments to study the tumorigenic activity of oestrogens such as DES.
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