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  • Title: Androgen-binding proteins in sheep epididymis: age-related effects on androgen-binding protein, cytosolic androgen receptor and testosterone concentrations. Correlations with histological studies.
    Author: Carreau S, Drosdowsky MA, Courot M.
    Journal: J Endocrinol; 1984 Dec; 103(3):281-6. PubMed ID: 6542125.
    Abstract:
    The androgen-binding protein (ABP) and the cytosol androgen receptor (Rc) were measured in the epididymis of sheep aged 50, 120 and 200 days. Specific binding protein was not detected at 50 days (infantile); near puberty (120 days), ABP was more concentrated in caput and cauda epididymal cytosols (117 and 183 fmol/mg protein respectively) than in corpus (53 fmol/mg) although Rc levels were low (3-5 fmol/mg). In postpubertal rams (200 days), ABP and Rc concentrations were higher in caput and cauda than in corpus epididymis. Testosterone concentrations at 50 days were not statistically different along the epididymis and varied from 0.3 to 0.8 pmol/mg protein. In 120-day-old animals, testosterone was more concentrated in caput and corpus (0.45 and 0.41 pmol/mg) than in cauda (0.17 pmol/mg); at 200 days, the testosterone contents were low (0.10-0.17 pmol/mg) in all parts of the epididymis. A ten-fold increase in plasma testosterone concentrations was observed between 50 and 200 days (1.31 to 11.71 nmol/l). Histological studies of the epididymis in the three groups of animals showed that the cell differentiation started in the cauda where the principal epithelial cells were higher (47-56 micron) than in the caput (31-38 micron) at 50 days. The principal cells of the caput were two- to threefold higher in postpubertal rams than in infantile lambs, a finding which is correlated with the levels of ABP and Rc. This may suggest an important physiological role of this region in the induction of sperm maturation.
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