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  • Title: Effect of tilorone hydrochloride on hepatic disposition of sulphobromophthalein (BSP) in the rat.
    Author: Hoenig V, Werner F.
    Journal: Xenobiotica; 1978 Mar; 8(3):157-63. PubMed ID: 654309.
    Abstract:
    1. Biliary excretion of sulphobromophthalein (BSP) was studied in male rats after oral administration of tilorone HCl, an anti-viral and anti-tumour agent. 2. The stimulation of bile flow by BSP was decreased 1 h after tilorone administration; this decrease was no longer apparent 24 h later but a fall of basal bile flow was noted at that time. No changes in bile flow were observed 7 days after this single dose. 3. Repeated dosing with tilorone produced a dose-dependent increase in hepatic concentration of unchanged and metabolized tilorone. This was associated with a dose-dependent decrease of bile formation and BSP excretion. Bile acid excretion was depressed as well. 4. BSP metabolism was not significantly affected by tilorone administration.
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