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  • Title: Enhancement (by native type II collagen) of the humoral immune response to native type I collagen in the rat.
    Author: Morgan K, Clague RB, Evans HB, Firth SA, Wallace JE, Holt PJ.
    Journal: Clin Exp Rheumatol; 1984; 2(1):17-22. PubMed ID: 6543436.
    Abstract:
    Both native type II collagen and rabbit IgG were good immunogens in the rat when emulsified in incomplete Freund's adjuvant but native type I collagen and denatured type II collagen were not. Both native type II collagen and rabbit IgG had an enhancing effect upon the production of antibodies to native type I collagen when rats were immunised with a mixture of native type I collagen and either of these immunogens but denatured type II collagen did not have this effect. These immunogens, however, did not enhance the production of antibodies to ovalbumin when emulsified with it. Although both native type II collagen and rabbit IgG showed this enhancing effect with native type I collagen, only rats immunised with native type II collagen or mixtures containing native type II collagen developed arthritis. Thus, a specific immune response to collagen rather than this enhancing effect appears to be necessary for the induction of arthritis.
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