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  • Title: Schedule-induced ethanol dependence and phenobarbital preference.
    Author: Tang M, Kenny J, Falk JL.
    Journal: Alcohol; 1984; 1(1):55-8. PubMed ID: 6543610.
    Abstract:
    Rats exposed to a daily 3-hr session of intermittent food delivery ingested physical-dependence-produced levels of 5% ethanol solution. Although this schedule induced a chronic, voluntary, daily overindulgence, this had no effect on 21-hr home-cage phenobarbital preference. The substitution of water for 5% ethanol during the daily 3-hr binge session did not change home-cage phenobarbital preference, which remained stable and similar to that of a control group of non-binging animals. This experiment and others indicate that physical dependence on ethanol does not play a major role in the maintenance of ethanol abuse or cross-abuse of the barbiturates.
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