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  • Title: Macromolecular organization and functional architecture of basement membranes.
    Author: Garbisa S, Negro A.
    Journal: Appl Pathol; 1984; 2(4):217-22. PubMed ID: 6545135.
    Abstract:
    Basement membranes (BMs) are extracellular laminar matrices produced by endothelial and epithelial cells. They are composed by three major intrinsic macromolecules: type IV collagen, laminin and heparan sulfate proteoglycan (HSP), and by two major extrinsic ones: fibronectin and type V collagen. The intrinsic components are assembled in a three-dimensional network (type IV collagen) to which cells stick (by laminin) and through which (HSP) they interact with the stromal compartment. The BM is a barrier to be crossed by any cell that leaves the stroma to enter into the circulation or vice versa. Metastatic tumor cells secrete a protease which specifically degrades the BM collagen and some evidence suggests that the same enzyme is used also by normal monocytes.
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