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  • Title: Effects of histamine-receptor agonists on transvascular fluid and macromolecular efflux in the canine forelimb.
    Author: Dobbins DE, Soika CY, Premen AJ, Dabney JM.
    Journal: Microcirc Endothelium Lymphatics; 1984 Aug; 1(4):431-51. PubMed ID: 6546153.
    Abstract:
    Histamine increases transvascular fluid and protein efflux in the canine forelimb resulting in edema formation. To clarify the receptor mechanisms of histamine edema, we infused H1 and H2-receptor agonists into the forelimb perfused at constant flow while measuring skin lymph parameters or forelimb weight. The H1-receptor agonist 2(2-pyridyl) ethylamine [PEA] or the H2-receptor agonist 4-methyl histamine (8-40 micrograms/min) singly or in combination fails to increase lymph flow, protein concentration or protein transport. PEA in a dose of 80-400 micrograms/min increases lymph flow, protein concentration and protein transport. 4-Methyl histamine in a dose of 40-200 micrograms/min produces a small but significant decrease in lymph flow and protein transport subsequent to a fall in systemic pressure. 4-Methyl histamine at 40 and 80 micrograms/min produces a progressive and sustained increase in forelimb weight PEA at 40 micrograms/min produces a small increase in forelimb weight which quickly plateaus much like the response seen with acetylcholine (10 micrograms base/min). However, infusion of PEA at 80 micrograms/min progressively increases forelimb weight, similar to that seen with 4-methyl histamine or histamine (1.4 microgram base/min). These data indicate that either H1 or H2-receptor agonists can cause edema formation in the canine forelimb, and imply that histamine edema involves both H1 and H2-receptor interaction.
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