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  • Title: Effect of fibroblast-pneumonocyte factor on the synthesis of surfactant phospholipids in type II cells from fetal rat lung.
    Author: Post M, Smith BT.
    Journal: Biochim Biophys Acta; 1984 Apr 18; 793(2):297-9. PubMed ID: 6546883.
    Abstract:
    The effect of fibroblast-pneumonocyte factor on the formation of surfactant-associated phospholipids was studied in fetal rat lung type II cells in primary culture. Exposure of the cells to fibroblast-pneumonocyte factor enhanced the incorporation of radioactively labelled choline, glycerol and palmitate into total and saturated phosphatidylcholine. Fibroblast-pneumonocyte factor also stimulated the formation of phosphatidylglycerol from labelled glycerol and palmitate but did not significantly affect the synthesis of the other phospholipids. This indicates that fibroblast-pneumonocyte factor specifically stimulates the production of surfactant lipids in fetal lung.
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