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  • Title: The sequence of an atriopeptigen: a precursor of the bioactive atrial peptides.
    Author: Geller DM, Currie MG, Siegel NR, Fok KF, Adams SP, Needleman P.
    Journal: Biochem Biophys Res Commun; 1984 Jun 29; 121(3):802-7. PubMed ID: 6547606.
    Abstract:
    The high molecular weight fraction ( atriopeptigen -APG) obtained by gel filtration chromatography of rat atrial extracts was fractionated by isoelectric focusing and reverse phase HPLC to obtain a pure APG. Purification of cyanogen bromide digests of the crude high molecular weight fraction resulted in the isolation of a single biologically active cyanogen bromide cleavage peptide. Sequence analyses of these peptides coupled with recent reports of sequence analyses of intermediate molecular weight atrial peptides ( Thibault , et al. (1984) FEBS Letters 167, 352-356, and Kangwa , et al., Biochem. Biophys. Res. Commun 119, 933-940) provide the complete primary structure of an 111 residue APG.
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