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Pubmed for Handhelds

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  • Title: A calculator program for least-squares parameter estimation according to the one-compartment kinetic model with zero-order input.
    Author: Messori A, Donati-Cori G, Tendi E.
    Journal: Comput Programs Biomed; 1984; 18(1-2):119-24. PubMed ID: 6547651.
    Abstract:
    A calculator program that performs a nonlinear least-squares fit to data conforming to the one-compartment model with zero-order input is described. The program, which is designed for the Hewlett-Packard HP-41 CV calculator, is based on the Gauss-Newton iterative algorithm as modified by Hartley. A subroutine for calculation of initial parameter estimates is incorporated into the program. Plasma concentration data relative to a single oral dose of a sustained-release theophylline formulation are used to demonstrate the practical application of the program.
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