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  • Title: A spirohydantoin derivative of dimethoxytetrahydronaphthalene: an experimental anticonvulsant.
    Author: Alexander GJ, Sinha B, Chatterjie N.
    Journal: Neurochem Res; 1984 Apr; 9(4):529-33. PubMed ID: 6547772.
    Abstract:
    A 2-spirohydantoin of 6,7-dimethoxytetrahydronaphthalene was synthesized and purified. The compound, showing structural similarities to both phenytoin and dopamine, was found to decrease spontaneous motor activity of mice and to exert a pronounced protective effect against convulsive seizures induced by pentylenetetrazol (Metrazol).
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