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  • Title: Neuromedin N: a novel neurotensin-like peptide identified in porcine spinal cord.
    Author: Minamino N, Kangawa K, Matsuo H.
    Journal: Biochem Biophys Res Commun; 1984 Jul 31; 122(2):542-9. PubMed ID: 6547840.
    Abstract:
    A novel neurotensin-like peptide, designated neuromedin N, has been isolated from porcine spinal cord by using a bioassay for a stimulant effect on guinea pig ileum. By microsequencing, the amino acid sequence of the peptide has been determined to be Lys-Ile-Pro-Tyr-Ile-Leu, which is found to be quite homologous to the COOH-terminal sequence of neurotensin. This structure has been confirmed by synthesis. Neuromedin N exhibits a contractile activity on guinea pig ileum and induces a hypotensive response in the rat similar to that with neurotensin. These findings suggest that neuromedin N may be a new neuromediator or hormone with a specific spectrum of biological activity.
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