These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Monolayer culture of bone marrow and splenic fibroblasts in lymphoproliferative diseases].
    Author: Domracheva EV, Rogova EM, Vorob'ev AI.
    Journal: Ter Arkh; 1984; 56(6):63-5. PubMed ID: 6548048.
    Abstract:
    The authors describe the results of monolayer cultivation bone marrow and spleen fibroblasts in patients with lymphoproliferative diseases. The efficacy of colony-formation of fibroblasts (ECFf) was studied in 10 patients with chronic lympholeukemia, 4 with leukemic reticuloendotheliosis, in 5 with lymphocytoma of the spleen, and in 3 with lymphosarcoma of the spleen. The control group comprised 7 normal subjects. Comparison of the ECFf on the spleen and bone marrow during lymphocytomas demonstrated the ECFf in the bone marrow to be low (0.24 +/- 0.16) in contrast to the high and normal ECFf in chronic lympholeukemia and leukemic reticuloendotheliosis. The ECFf in the spleen of patients with lymphocytomas was high (4.20 +/- 0.90), i. e. higher than in the control group (1.1 +/- 0.31). In lymphosarcoma of the spleen, the growth of fibroblasts was low in both the bone marrow and the spleen (0.15 +/- 0.13 and 0.10 +/- 0.01). These data suggest that the growth of stromal elements in lymphatic tumors is determined by the characteristic features of tumor cells.
    [Abstract] [Full Text] [Related] [New Search]