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  • Title: Chemical changes of human knee joint menisci in various stages of degeneration.
    Author: Herwig J, Egner E, Buddecke E.
    Journal: Ann Rheum Dis; 1984 Aug; 43(4):635-40. PubMed ID: 6548109.
    Abstract:
    Human knee joint menisci graded according to degenerative alterations were submitted to chemical analysis. Normal menisci contained 72% water, 0.12% DNA, 22% collagen, and 0.8% total glycosaminoglycans with the following glycosaminoglycan distribution pattern: 40% chondroitin 6-sulphate, 10-20% chondroitin 4-sulphate, 20-30% dermatan sulphate, and 15% keratan sulphate. The water content increased with increasing degeneration, whereas the collagen and glycosaminoglycan contents decreased with relative increase of chondroitin 6-sulphate.
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