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  • Title: Amino terminal fragments of human progastrin from gastrinoma.
    Author: Reeve JR, Walsh JH, Tompkins RK, Hawke D, Shively JE.
    Journal: Biochem Biophys Res Commun; 1984 Aug 30; 123(1):404-9. PubMed ID: 6548139.
    Abstract:
    Two peptides which copurified from a human gastrinoma were found to correspond to the amino acid sequence deduced for the amino terminal portion of human and porcine progastrin. The sequence of peptide A is Ser-Trp-Lys-Pro-Arg-Ser-Gln-Gln-Pro-Asp-Ala-Pro-Leu-Gly-Thr-Gly-Ala-Asn- Arg-Asp-Leu-Glu-Leu which is identical to an amino terminal portion of human progastrin. The sequence of peptide. B is identical to that of peptide A except it is missing the first five amino acids. If peptide A corresponds to the amino terminus of progastrin, the signal peptidase cleaves at an Ala-Ser bond.
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