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  • Title: Effects of DSIP on narcolepsy.
    Author: Schneider-Helmert D.
    Journal: Eur Neurol; 1984; 23(5):353-7. PubMed ID: 6548968.
    Abstract:
    Repeated injections of delta sleep-inducing peptide (DSIP) were given to a 35-year-old male narcoleptic. Effects on wakefulness and sleep were evaluated by self-reports, performance tests, multiple sleep latency test and all-night polysomnography. DSIP reduced the frequency of sleep attacks and increased activity, alertness and performance during day-time. The sleep period was compressed by DSIP with enhancement of REM sleep. The results suggest that the effects are due to an accentuation of circadian and ultradian rhythms by DSIP.
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