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  • Title: Detection of kallikrein-like activity in inflamed synovial tissue.
    Author: Sharma JN, Zeitlin IJ, Deodhar SD, Buchanan WW.
    Journal: Arch Int Pharmacodyn Ther; 1983 Apr; 262(2):279-86. PubMed ID: 6553485.
    Abstract:
    The synovial tissue kallikrein of rheumatoid patients, arthritic dogs and normal dogs has been partially characterized and estimated. Both human and dog synovial tissue kinin-forming enzyme appears to be distinct from plasmin, plasma kallikrein and pancreatic kallikrein. In three rheumatoid arthritic patients, the mean synovial tissue kallikrein level was found to be 106 +/- 13.5 ng bradykinin equivalents (BK Equiv) per g per min. In nine arthritic dogs the mean synovial tissue kallikrein level, 60.5 +/- 4.5 ng BK Equiv per g per min, was found to be greater (p less than 0.05) than that of five normal dogs (21.6 +/- 5.3 ng BK Equiv per g per min). The possible significance of this finding is discussed.
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