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  • Title: Desmosine and isodesmosine contents and elastase activity in normal and cirrhotic rat liver.
    Author: Velebný V, Kasafírek E, Kanta J.
    Journal: Biochem J; 1983 Sep 15; 214(3):1023-5. PubMed ID: 6556069.
    Abstract:
    The contents of desmosine and isodesmosine, the cross-linking amino acids of elastin, were increased 4-fold in rat liver with carbon tetrachloride-induced cirrhosis, which suggests that insoluble elastin accumulates in cirrhosis. Elastase activity in the cirrhotic liver, as determined with 3-carboxypropionyl-L-alanyl-L-alanyl-L-alanine p-nitroanilide, was 17% less than in the normal liver; no change was found when Congo Red-elastin was used as a substrate.
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