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  • Title: Specific inhibition of human leukocyte elastase by substituted alpha-pyrones.
    Author: Groutas WC, Abrams WR, Carroll RT, Moi MK, Miller KE, Margolis MT.
    Journal: Experientia; 1984 Apr 15; 40(4):361-2. PubMed ID: 6562017.
    Abstract:
    Several a-pyrones have been synthesized and investigated for their in vitro inhibitory activity using a-chymotrypsin (a-CT), porcine pancreatic elastase (PPE) and human leukocyte elastase (HLE). 4-Hydroxy-6-undecyl-2H-pyran-2-one 4, 4-Hydroxy-6-[(1-butyl)heptyl]-2H-pyran-2-one 5 and 4-Methoxy-6-[(1-butyl) heptyl]-2H-pyran-2-one 6 were found to be specific inhibitors of HLE. These compounds constitute a promising new class of HLE inhibitors.
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