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  • Title: [Effect of neuroleptics on acetylcholine metabolism in the basal ganglia of the brain].
    Author: Balakleevskiĭ AI, Maslova IV.
    Journal: Biull Eksp Biol Med; 1978 Apr; 85(4):429-31. PubMed ID: 656581.
    Abstract:
    Neuroleptics (haloperidol) closapine, pimozid, chlorpromazine) diminished the level of free (functionally active) form of acetylcholine (ACh), and, to some extent, the bound form of ACh; they changed the content of the labile-bound (vesicular) form of ACh and weakly influenced the choline-acetyltranspherase activity in the basal ganglia of the rat brain 5 to 30 min after the injection. In contrast to the inhibitory action on the acetyl-cholinesterase (AChE) activity in vitro, most of the neuroleptics, except closapine, increased the AChE activity in vivo. These results indicate that the neuroleptics activate ACh-metabolism and probably stimulate the cholinergic structure in the basal ganglia of the brain; the AChE activity may serve as a criterion of such stimulating action of neuroleptics.
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