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  • Title: Serum immune complexes and disease activity in lupus nephritis.
    Author: Levinsky RJ, Cameron JS, Soothill JF.
    Journal: Lancet; 1977 Mar 12; 1(8011):564-7. PubMed ID: 65659.
    Abstract:
    Raised levels of circulating soluble immune complexes were found in sera of 21 of 29 patients with lupus nephritis. They correlated well with clinical disease activity in the group as a whole and with the course of individual patients. In 2 patients, high-dose methylprednisolone reduced levels of immune complexes and led to clinical improvement. The size of the IgG complexes was studied in 7 patients. The complexes were very large (2-5-4X10(6) M.W.) in 6, but only the 4 with diffuse proliferative glomerulonephritis had medium-sized IgG complexes (1-1-5X10(6) M.W.) as well.
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