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  • Title: [Characteristics of mitosis pathology in a Chinese hamster cell culture with disorders of the protein-synthesizing system].
    Author: Alov IA, Strochkova LS.
    Journal: Biull Eksp Biol Med; 1978 May; 85(5):605-8. PubMed ID: 656611.
    Abstract:
    Disturbance of protein synthesis with puromycin and transcription of chromosomal and ribosomal RNA with actinomycin D was followed by marked changes in the normal course of mitosis. There was noted an increase in number of colchicin-like mitoses (C-mitoses), and particularly, sometimes, fragmentation of their cytoplasm with the formation of cluster-like structures. It is suggested that development of C-mitosis was connected not only with destruction in the mitotic apparatus formation system, but also with the block of synthesis of one of the chromosomal proteins, stabilizing DNA strands spiralization. Another form of pathological mitosis occurring under conditions of suppression of the metabolic processes ("hollow metaphase plate") was linked not only with the chromosomal alterations. Selective suppression of the ribosomal RNA transcription led to an evident anaphase delay and to coupling of telomere regions of chromosomes. This phenomenon is apparently associated with destruction of the "protective cover" of chromosomes, formed by RNA of the disintegrating nucleoli and RNA of perichromatin granules.
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