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  • Title: [Activation of the kallikrein-kinin system by clonidine].
    Author: Kühne H, Schlagehan IM, Lehmann B, Hinkel GK, Scheuch DW.
    Journal: Z Gesamte Inn Med; 1984 Nov 15; 39(22):566-9. PubMed ID: 6570395.
    Abstract:
    Our results show that after the application of clonidine an activation of the kallikrein kinin system develops. The activation is characterized by the proof of active kallikrein and the decrease of kallikreinogen and the inhibitor capacity against kallikrein and trypsin. The extent of the activation seems to depend on the dosage of clonidine. The more pronounced reaction of the kallikrein kinin system might be connected with the side effects observed in the clonidine test.
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