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  • Title: In vitro caries-like lesion formation in F-containing tooth enamel.
    Author: LeGeros RZ, Silverstone LM, Daculsi G, Kerebel LM.
    Journal: J Dent Res; 1983 Feb; 62(2):138-44. PubMed ID: 6571867.
    Abstract:
    In vitro caries-like lesion formation in F-containing tooth enamel (shark) showed a lower depth of penetration compared to that in human enamel (42 vs. 100%). After longer periods of exposure, the depth of penetration in shark enamel is only 33% relative to that in human enamel. The extent of dissolution in acetate buffer for powdered human enamel and for synthetic F-free calcium-carbonated-apatites was greater than for powdered shark enamel and for synthetic F-containing apatites. These results suggest that the cariostatic action of fluoride may be explained in terms of a combination of two effects: (a) the stabilizing effect against acid dissolution (caries) when fluoride is incorporated in the tooth mineral (apatite), and (b) a greater degree of remineralization (repair) in the presence of F solution.
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