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  • Title: Competitive advantage of diferric transferrin in delivering iron to reticulocytes.
    Author: Huebers HA, Csiba E, Huebers E, Finch CA.
    Journal: Proc Natl Acad Sci U S A; 1983 Jan; 80(1):300-4. PubMed ID: 6572005.
    Abstract:
    Radioiron- and radioiodine-labeled forms of human diferric and monoferric transferrin and apotransferrin, isolated by preparative isoelectric focusing, were used to define transferrin-iron uptake by human reticulocytes. In mixtures of human diferric and monoferric transferrin, the diferric molecule had a constant 7-fold advantage in delivering iron to reticulocytes, as compared with the 2-fold advantage when single solutions of mono- and diferric transferrins were compared. This was shown to be due to competitive interaction in iron delivery, probably at a common membrane-receptor binding site for transferrin. Apotransferrin did not interfere with the iron-donating process and its limited cellular uptake was inhibited in noncompetitive fashion by diferric transferrin.
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