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  • Title: A case of chronic myeloid leukemia without Ph1 translocation.
    Author: Rolović Z, Cirić M, Mijović A.
    Journal: Cancer Genet Cytogenet; 1983 Jan; 8(1):75-9. PubMed ID: 6572550.
    Abstract:
    A case of chronic myeloid leukemia (CML) with a short survival (11 months) is described. Cytogenetic peculiarities of the bone marrow cells analyzed by G-banding consisted of a Ph1 chromosome with no translocation and a translocation t(5;13). Hematological characteristics were marked leukocytosis and massive splenomegaly. After treatment with busulfan complete hematological remission was achieved, followed by the appearance of a normal clone. However, 6 months later the patient entered the blastic crisis and a hyperdiploid clone appeared. The usual chemotherapy was given, but the patient responded only partially and died with a prevalence of pathologic myeloblasts in the bone marrow, corresponding to progression of the hyperdiploid clone.
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